At least six people were killed and roughly two dozen injured Monday after a pair of gunmen opened fire at a bus stop in Jerusalem, Israeli officials said. It is the deadliest attack on civilians in Israel since two Palestinian assailants carried out a mass shooting in Tel Aviv in October.

The attackers were killed at the scene, Israeli police said, after a security officer and a civilian returned fire. Israel’s domestic intelligence agency, Shin Bet, identified the gunmen as Muthna Amro, 20, and Muhammad Taha, 21, both from villages in the occupied West Bank.

The Palestinian Authority, the body that governs the Palestinian-controlled parts of the West Bank, condemned the attack and “any targeting of Palestinian and Israeli civilians.” Hamas and Palestinian Islamic Jihad both issued statements praising the shooting, which they described as a “natural” response to Israeli actions in the West Bank and Gaza Strip. Neither group claimed responsibility for the attack.

The gunfire started shortly after 10 a.m. local time at the Ramot Junction in northern Jerusalem, according to Israel’s Magen David Adom (MDA) emergency services. The busy intersection is a waypoint for travel to Israeli settlements in East Jerusalem and the West Bank, and witnesses speaking to Israeli media said the attackers boarded a bus and opened fire.

The Palestinian Authority, the body that governs the Palestinian-controlled parts of the West Bank, condemned the attack and “any targeting of Palestinian and Israeli civilians.” Hamas and Palestinian Islamic Jihad both issued statements praising the shooting, which they described as a “natural” response to Israeli actions in the West Bank and Gaza Strip. Neither group claimed responsibility for the attack.

The gunfire started shortly after 10 a.m. local time at the Ramot Junction in northern Jerusalem, according to Israel’s Magen David Adom (MDA) emergency services. The busy intersection is a waypoint for travel to Israeli settlements in East Jerusalem and the West Bank, and witnesses speaking to Israeli media said the attackers boarded a bus and opened fire.

Dash cam footage shared on social media showed bumper-to-bumper traffic near the bus stop, and then a stream of people running away as dozens of gunshots rang out.

The dead included a man around 50 years old and three men around age 30, MDA said in a statement. At least five other people were wounded by gunfire and evacuated to hospitals in Jerusalem, while additional victims with minor injuries, including from glass shards, were treated at the scene, the paramedics said. Israeli police said a security officer and a civilian “responded immediately, returned fire and neutralized the attackers.”

“We are at war, an intense war against terrorism on several fronts,” Israeli Prime Minister Benjamin Netanyahu said, speaking at the scene of the attack. “We are now engaged in pursuit and are cordoning off the villages from which the murderers came. We will apprehend whoever aided and dispatched them, and we will take even stronger steps."

Troops were dispatched to the scene and were searching for additional suspects in coordination with the police, the Israel Defense Forces said in a statement. “Soldiers are currently encircling several areas” on the outskirts of the West Bank city of Ramallah, the IDF said shortly after the shooting. On Monday evening, the top IDF commander, chief of staff Lt. Gen. Eyal Zamir, said he had ordered the “full closure” of the West Bank area near the homes of the dead suspects.

One of them, the 20-year-old Amro, had been detained during an IDF raid on his home on June 9, according to the Palestinian WAFA news agency. It’s not clear why Amro was under investigation, but he was released by the Israelis after several hours, said Izzat Hamouda, a journalist who lives in Amro’s village, Al Qubeiba.

About an hour after news of the shooting broke on Monday, Hamouda said, Israeli troops in armored vehicles entered Al Qubeiba, closed the main entrances and the roads to Ramallah, and surrounded Amro’s home. After a five-hour interrogation, the Israelis arrested Amro’s father and brother and left, said Hamouda, who described Amro as a student at Birzeit University and his family as financially well-off.

Relatives of Taha, the other alleged shooter from Qattana village, were also taken away, local media reported.