United States President Donald Trump posted on Truth Social, saying, "Congratulations to Cardinal Robert Francis Prevost, who was just named Pope. It is such an honor to realize that he is the first American Pope. What excitement, and what a Great Honor for our Country. I look forward to meeting Pope Leo XIV. It will be a very meaningful moment!"

U.S Vice President JD Vance

United States Vice President JD Vance posted to X, saying, "Congratulations to Leo XIV, the first American Pope, on his election! I’m sure millions of American Catholics and other Christians will pray for his successful work leading the Church. May God bless him!"

Former President Barack Obama

Former United States President Barack Obama posted to X, saying, "Michelle and I send our congratulations to a fellow Chicagoan, His Holiness Pope Leo XIV. This is a historic day for the United States, and we will pray for him as he begins the sacred work of leading the Catholic Church and setting an example for so many, regardless of faith."

Chicago Mayor Brandon Johnson

Chicago Mayor Brandon Johnson posted on X, "Everything dope, including the Pope, comes from Chicago! Congratulations to the first American Pope Leo XIV! We hope to welcome you back home soon."

Ukraine President Volodymyr Zelensky

Ukraine President Volodymyr Zelensky posted on X, “Ukraine deeply values the Holy See’s consistent position in upholding international law, condemning the Russian Federation’s military aggression against Ukraine, and protecting the rights of innocent civilians. At this decisive moment for our country, we hope for the continued moral and spiritual support of the Vatican in Ukraine’s efforts to restore justice and achieve a lasting peace.”

Italian Prime Minister Giorgia Meloni

Italian Prime Minister Giorgia Meloni posted on X, "I extend my most sincere wishes to Pope Leo XIV for the beginning of his pontificate.In a time marked by conflict and unrest, his words from the Loggia delle Benedizioni are a powerful call for peace, brotherhood and responsibility.A spiritual legacy that follows the path traced by Pope Francis, and that Italy looks at with respect and hope."

Ireland Prime Minister Michael Martin

Ireland’s Prime Minister, Micheal Martin, posted on X, “The scenes of great joy and celebrations in St. Peter’s Square are a reflection of the hopes and goodwill felt by people of the Catholic faith from all around the world towards the new Pope,” he said. “I hope that this ground swell of best wishes towards Pope Leo XIV will give him strength and support as he takes on the immense responsibility of his pontificate. I know that he has the best wishes of all Irish people, of all traditions.”