Suspected Israeli warplanes bombed Iran's embassy in Syria on Monday in a strike that Iran said killed seven of its military advisers, including three senior commanders, marking a major escalation in Israel's war with its regional adversaries.

Reuters reporters at the site in the Mezzeh district of Damascus saw emergency workers clambering atop rubble of a destroyed building inside the diplomatic compound, adjacent to the main Iranian embassy building. Emergency vehicles were parked outside. An Iranian flag hung from a pole by the debris.

"We strongly condemn this atrocious terrorist attack that targeted the Iranian consulate building in Damascus and killed a number of innocents," said Syrian Foreign Minister Faisal Mekdad who was seen at the site along with Syria's interior minister.

Iran's ambassador to Syria said the strike hit a consular building in the embassy compound and that his residence was on the top two floors.

Iran's Islamic Revolutionary Guard Corps said in a statement that seven Iranian military advisers died in the strike including Mohammad Reza Zahedi, a senior commander in its Quds Force, which is an elite foreign espionage and paramilitary arm.

Israel has long targeted Iran's military installations in Syria and those of its proxies, but Monday's attack was the first time Israel hit the vast embassy compound itself.

It has ramped up those strikes in parallel with its campaign against Iran-backed Palestinian group Hamas, which ignited the Gaza war with an Oct. 7 attack on Israel that killed about 1,200 people and took 253 hostage, according to Israeli tallies.

More than 32,000 Palestinians have been killed in Israel's offensive in Gaza, according to Palestinian health authorities.

Israel' military has escalated airstrikes in Syria against Iran's Islamic Revolutionary Guard Corps and the Iranian-backed Lebanese armed group Hezbollah, both of which support Syrian President Bashar al-Assad.

Israel typically does not discuss attacks by its forces on Syria. Asked about the strike, an Israeli military spokesperson said: "We do not comment on reports in the foreign media".

The New York Times cited four unnamed Israeli officials as acknowledging Israel had carried out the attack.

Iran's U.N. mission described the strike as a "flagrant violation of the United Nations Charter, international law, and the foundational principle of the inviolability of diplomatic and consular premises."

Saying the strike was "a significant threat to regional peace and security," the Iranian mission urged the U.N. Security Council to condemn the attack and said Tehran reserved the right "to take a decisive response."

Hezbollah, the Lebanese group seen as Iran's most powerful armed proxy in the region, vowed to retaliate. "This crime will not pass without the enemy receiving punishment and revenge," the group said in a statement.